The production of SDH (succinate dehydrogenase) occurs in the outer membrane of the cell's mitochondria.   The process is associated with the Krebs/Szent-Gyorgi Cycle and is important because it is associated with the below muscular and neuro degenerative  diseases:

 

  • Aging & Longevity,
  • Alpers' ( infantile poliodystrophy)
  • Alzheimer's
  • Aminoaciduria Colestasis
  • Ataxia
  • Barth syndrome 
  • Cardiomyopathy
  • Fatal infantile Growth Retardation
  • Gastro Intestine Encephalopathy (MNGIE)  
  • Infantile Encephalopathy
  • Infantile Central nervous System (CNS)
  • Iron overload Lactosis and Early death (GRACILE)
  • Kearns-Sayre Syndrome (KSS)
  • Lactic Acidosis (MELAS)
  • Leber's Syndrone
  • Leigh's
  • Mitochondrial Encephalopathy
  • Myoclonic Epilepsy with Ragged Red Fibers (MERRF)
  • Myopathy
  • Neuropathy Ataxia
  • Parkinson's
  • Paraganglioma
  • Pheochromocytoma 
  • Progressing External Ophthalmoplegia (PEO)
  • Retinitis Pigmentosa (NARP)
  • Rhabdomyolysis

   The use of volitional exercising and complementary electrical stimulation may be associated with an increase in SDH, or following injury and some diseases the possibility of maintenance of SDH production.  It is not known if injury and disease processes cause a reduction in SDH production, or require an increase to deal with the prevailing condition.